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Effect of Phenotype Selection on Genome Size Variation in Two Species of Diptera

Authors
  • Hjelmen, Carl E.1, 2
  • Parrott, Jonathan J.1, 3
  • Srivastav, Satyam P.1, 4
  • McGuane, Alexander S.1, 5
  • Ellis, Lisa L.1, 6
  • Stewart, Andrew D.
  • Johnston, J. Spencer1
  • Tarone, Aaron M.1
  • 1 (A.M.T.)
  • 2 Department of Biology, Texas A&M University, College Station, TX 77843, USA
  • 3 School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA
  • 4 Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
  • 5 Harris County Institute of Forensic Sciences, 1861 Old Spanish Trail, Houston, TX 77054, USA
  • 6 Department of Biology, Houston Baptist University, Houston, TX 77074, USA
Type
Published Article
Journal
Genes
Publisher
MDPI AG
Publication Date
Feb 19, 2020
Volume
11
Issue
2
Identifiers
DOI: 10.3390/genes11020218
PMID: 32093067
PMCID: PMC7074110
Source
PubMed Central
Keywords
License
Green

Abstract

Genome size varies widely across organisms yet has not been found to be related to organismal complexity in eukaryotes. While there is no evidence for a relationship with complexity, there is evidence to suggest that other phenotypic characteristics, such as nucleus size and cell-cycle time, are associated with genome size, body size, and development rate. However, what is unknown is how the selection for divergent phenotypic traits may indirectly affect genome size. Drosophila melanogaster were selected for small and large body size for up to 220 generations, while Cochliomyia macellaria were selected for 32 generations for fast and slow development. Size in D. melanogaster significantly changed in terms of both cell-count and genome size in isolines, but only the cell-count changed in lines which were maintained at larger effective population sizes. Larger genome sizes only occurred in a subset of D. melanogaster isolines originated from flies selected for their large body size. Selection for development time did not change average genome size yet decreased the within-population variation in genome size with increasing generations of selection. This decrease in variation and convergence on a similar mean genome size was not in correspondence with phenotypic variation and suggests stabilizing selection on genome size in laboratory conditions.

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