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Effect of perfluorohexane on the expression of cellular adhesion molecules and surfactant protein A in human mesothelial cells in vitro.

Authors
  • Haufe, Dirk
  • Dahmen, Klaus G
  • Tiebel, Oliver
  • Hübler, Matthias
  • Koch, Thea
Type
Published Article
Journal
Artificial cells, blood substitutes, and immobilization biotechnology
Publication Date
Aug 01, 2011
Volume
39
Issue
4
Pages
239–246
Identifiers
DOI: 10.3109/10731199.2010.550264
PMID: 21261566
Source
Medline
License
Unknown

Abstract

The intraperitoneal instillation of perfluorocarbons augmented systemic oxygenation and was protective in mesenteric ischemia-reperfusion and experimental lung injury. To study biocompatibility and potential anti-inflammatory effects of intraperitoneal perfluorocarbons, we evaluated the influence of perfluorohexane and/or inflammatory stimuli on human mesothelial cells in vitro. Perfluorohexane exposure neither impaired cell viability nor induced cellular activation. TNFα enhanced ICAM-1 expression, which was not attenuated by simultaneous perfluorohexane treatment. Concentration of intracellular surfactant protein A tended to be higher in perfluorohexane treated cells compared to controls. Our in vitro data add further evidence that intraperitoneal perfluorocarbon application is feasible without adverse local effects.

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