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Effect on the offspring of pregnant females CD-1 mice treated with a single thallium(I) application.

Authors
  • Álvarez-Barrera, Lucila1
  • Rodríguez-Mercado, Juan J1
  • Mateos-Nava, Rodrigo A1
  • Vázquez-Martínez, Yazmín1
  • Altamirano-Lozano, Mario A2
  • 1 Unidad de Investigación en Genética y Toxicología Ambiental, Laboratorio 5 primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIE-Z), Facultad de Estudios Superiores-Zaragoza, UNAM. Campus II, Ciudad de México, Mexico, CP 15000. , (Mexico)
  • 2 Unidad de Investigación en Genética y Toxicología Ambiental, Laboratorio 5 primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIE-Z), Facultad de Estudios Superiores-Zaragoza, UNAM. Campus II, Ciudad de México, Mexico, CP 15000. Electronic address: [email protected] , (Mexico)
Type
Published Article
Journal
Reproductive toxicology (Elmsford, N.Y.)
Publication Date
Dec 01, 2019
Volume
90
Pages
1–7
Identifiers
DOI: 10.1016/j.reprotox.2019.07.022
PMID: 31386884
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Thallium (Tl) is a highly toxic metal for human beings; higher amounts found in diverse fluids of pregnant women are associated with low birth weight and preterm birth. However, experimental data concerning their effects on the embryonic development of mammalian organisms are limited. Hence, in the present work, TI(I) acetate of 0, 4.6, 9.2, or 18.5 mg/kg body weight were administered by intraperitoneal injection to groups of 10 pregnant CD-1 mice on the 7th gestational day, and animals were sacrificed on day 18 of gestation. The fetuses obtained showed some variations, such as trunk bent over (18.5 mg/kg), tail variations (all doses), forelimbs malrotation and hind limbs (all doses). Skeletal examination of the fetuses showed a delay in the ossification of skull bones, ribs, and limbs (all doses). In conclusion, the Intraperitoneal injection of Tl(I) acetate to pregnant mice induced morphological variations and a delay of the fetus ossification. Copyright © 2019 Elsevier Inc. All rights reserved.

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