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Effect of mannose-binding protein on binding of Cryptococcus neoformans to human phagocytes.

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PMC
Keywords
  • Research Article
Disciplines
  • Biology

Abstract

The capacity of human peripheral blood monocytes, neutrophils, and monocyte-derived macrophages to bind the yeast Cryptococcus neoformans was increased when the phagocytes were cultured on surfaces containing recombinant human mannose-binding protein. In contrast, soluble mannose-binding protein had no effect on cryptococcal binding by phagocytes.

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