Affordable Access

deepdyve-link
Publisher Website

Effect of imatinib on the signal transduction cascade regulating telomerase activity in K562 (BCR-ABL-positive) cells sensitive and resistant to imatinib.

Authors
  • Mor-Tzuntz, Rahav1
  • Uziel, Orit
  • Shpilberg, Ofer
  • Lahav, Judith
  • Raanani, Pia
  • Bakhanashvili, Mary
  • Rabizadeh, Esther
  • Zimra, Yael
  • Lahav, Meir
  • Granot, Galit
  • 1 Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel. , (Israel)
Type
Published Article
Journal
Experimental hematology
Publication Date
January 2010
Volume
38
Issue
1
Pages
27–37
Identifiers
DOI: 10.1016/j.exphem.2009.10.005
PMID: 19837126
Source
Medline
License
Unknown

Abstract

We demonstrate an inhibitory effect of IM on TA and on the AKT/PDK pathway. Because this effect was observed in cell expressing the BCR-ABL protein as well as cells not expressing it, and in cells sensitive as well as resistant to IM, it is reasonable to assume that the inhibitory effect of IM on TA is not mediated through known IM targets. The results of this study show that cells resistant to IM with regard to its effect on BCR-ABL could still be sensitive to IM treatment regarding other cellular components.

Report this publication

Statistics

Seen <100 times