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Effect of extracorporeal liver support by MARS and Prometheus on serum cytokines in acute-on-chronic liver failure

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BioMed Central
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cc5119.fm Available online http://ccforum.com/content/10/6/R169 Open AccessVol 10 No 6Research Effect of extracorporeal liver support by MARS and Prometheus on serum cytokines in acute-on-chronic liver failure Vanessa Stadlbauer1, Peter Krisper2, Reingard Aigner3, Bernd Haditsch2, Aleksandra Jung4, Carolin Lackner5 and Rudolf E Stauber1 1Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria 2Department of Internal Medicine, Division of Nephrology and Hemodialysis, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria 3Department of Radiology, Division of Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 9, 8036 Graz, Austria 4Department of Medical Physics, AGH University of Science and Technology, Mickiewicza Ave, PL-30 059 Krakow, Poland 5Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria Corresponding author: Rudolf E Stauber, [email protected] Received: 4 Oct 2006 Revisions requested: 6 Nov 2006 Revisions received: 15 Nov 2006 Accepted: 7 Dec 2006 Published: 7 Dec 2006 Critical Care 2006, 10:R169 (doi:10.1186/cc5119) This article is online at: http://ccforum.com/content/10/6/R169 © 2006 Stadlbauer et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Cytokines are believed to play an important role in acute-on-chronic liver failure (ACLF). Extracorporeal liver support systems may exert beneficial effects in ACLF via removal of cytokines. At present, two systems are commercially available, the Molecular Adsorbent Recirculating System (MARS™) and Fractionated Plasma Separation, Adsorption and Dialysis (Prometheus™). The aim of this

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