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The effect of a new calcium antagonist, TA3090 (clentiazem), on experimental transient focal cerebral ischemia in cats.

Authors
  • Sakaki, T
  • Tsujimoto, S
  • Sasaoka, Y
  • Tsunoda, S
  • Shintomi, K
Type
Published Article
Journal
Stroke; a journal of cerebral circulation
Publication Date
Jun 01, 1993
Volume
24
Issue
6
Identifiers
PMID: 8506559
Source
Medline
License
Unknown

Abstract

1) TA3090 dilates pial arteries and increases cerebral blood flow in normal brain regions in a dose-response fashion; 2) in ischemic regions compared with those in untreated animals, TA3090 results in a lesser reduction of cerebral blood flow during ischemia and in a lesser degree of hyperemia during reperfusion; 3) TA3090 is associated with less pial artery dilatation during ischemia, presumably due to improved collateral flow; and 4) the improved hemodynamic state with TA3090 is associated with significant reduction of cerebral edema and infarct size.

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