The effect of neuropeptide Y on voltage-sensitive Ca2+ channels.
Pharmacology and Therapeutics, Defence Research Establishment Suffield, Alberta, Canada.
- Published Article
European Journal of Pharmacology
- Publication Date
Jan 17, 1991
Neuropeptide Y (NPY) (50-1000 nM) failed to modify basal or K(+)-stimulated Ca2+ influx in cortical or hippocampal synaptosomes from rat brain, whereas the voltage-sensitive Ca2+ channel (VSCC) blocker Cd2+ (50 microM) caused major inhibition. In cortical synaptosomes from chicken brain NPY (1.0 microM) failed to modify, whereas omega-conotoxin GV1A (0.1 microM) markedly inhibited Ca2+ influx. NPY does not appear to modify synaptosomal Ca2+ influx, however it may still affect VSCCs spatially distinct or 'upstream' from the nerve terminals.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2055242