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The effect of neuropeptide Y on voltage-sensitive Ca2+ channels.

Authors
  • Lundy, P M1
  • Frew, R
  • 1 Pharmacology and Therapeutics, Defence Research Establishment Suffield, Alberta, Canada. , (Canada)
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Jan 17, 1991
Volume
192
Issue
3
Pages
439–441
Identifiers
PMID: 2055242
Source
Medline
License
Unknown

Abstract

Neuropeptide Y (NPY) (50-1000 nM) failed to modify basal or K(+)-stimulated Ca2+ influx in cortical or hippocampal synaptosomes from rat brain, whereas the voltage-sensitive Ca2+ channel (VSCC) blocker Cd2+ (50 microM) caused major inhibition. In cortical synaptosomes from chicken brain NPY (1.0 microM) failed to modify, whereas omega-conotoxin GV1A (0.1 microM) markedly inhibited Ca2+ influx. NPY does not appear to modify synaptosomal Ca2+ influx, however it may still affect VSCCs spatially distinct or 'upstream' from the nerve terminals.

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