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[Effect of natural ribonucleotides on the ATP receptors of the neurons of the rat nodose ganglion].

Authors
  • Marchenko, S M
  • Obukhov, A G
  • Volkova, T M
Type
Published Article
Journal
Neir̆ofiziologiia = Neurophysiology
Publication Date
Jan 01, 1988
Volume
20
Issue
3
Pages
410–412
Identifiers
PMID: 3173583
Source
Medline
License
Unknown

Abstract

Action of natural ribonucleotides on ATP receptors of rat nodose ganglion has been studied. Nucleotides containing guanine, uracil or hypoxanthine residues as nitrogen base are competitive blockers of the receptors. Their pharmacological activity decreases along with reduction of the polyphosphate chain length. The most efficient blocker among them is guanosine-5'-triphosphate. Cytidine nucleotides as well as adenine ones are agonists of ATP receptors, if their polyphosphate chain contains two or three phosphate residues and are blockers, if it contains only one residue.

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