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Effect of N6-(delta2-isopentenyl)adenosine treatment in vivo on hexokinase activity of mouse L 1210 cells.

Authors
  • Shavelson, L J
  • Tritsch, G L
Type
Published Article
Journal
Journal of medicine
Publication Date
Jan 01, 1975
Volume
6
Issue
2
Pages
181–188
Identifiers
PMID: 1057642
Source
Medline
License
Unknown

Abstract

The kinetic properties of hexokinase of L1210 ascites tumor cells propagated in DBA/2HaD mice are altered by treatment of the mice with the modified nucleoside N6-(delta2-isopentenyl)-adensone (IPA). Relative to animals not treated with IPA, ascites cell hexokinase showed an increased affinity for ATP and a decreased affinity for glucose as a result of IPA treatment. The heat stability of the enzyme was different in treated and untreated mice. It was concluded that IPA treatment may either produce changes in enzyme conformation which resulted in a change in control mechanisms or may induce the formation of a hexokinase isoenzyme.

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