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Effect of morphine on circling behaviour in rats with 6-hydroxydopamine striatal lesions and electrolesions of the raphe nucleus.

Authors
Type
Published Article
Journal
Pharmacology Biochemistry and Behavior
0091-3057
Publisher
Elsevier
Publication Date
Volume
14
Issue
5
Pages
625–630
Identifiers
PMID: 7195577
Source
Medline

Abstract

Morphine antagonized d-amphetamine circling in rats which had received unilateral 6-OHDA lesions of the striatum but failed to reduce the circling in rats with both a unilateral 6-OHDA striatal lesion and a raphe (5-HT) lesion. Naloxone precipitated withdrawal of morphine tolerant rats greatly enhanced d-amphetamine circling when the rats had a 6-OHDA lesion but not when both 6-OHDA and raphe lesions were present. It is concluded that 5-HT is necessary for the morphine-induced inhibition of the circling. The effect of morphine tolerance and naloxone precipitated withdrawal on brain 5-HT function was investigated using a putative 5-HT rotation model in which both a dopamine and a 5-HT agonist were administered to rats with an asymmetrical medial raphe lesion. The findings suggest that chronic treatment with morphine increases striatal 5-HT function.

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