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Effect of medroxyprogesterone acetate upon PHA, Con A and PWM stimulated lymphocytes and on E-rosette function.

Authors
  • Corsini, G
  • Puppo, F
Type
Published Article
Journal
Journal of immunopharmacology
Publication Date
Jan 01, 1982
Volume
4
Issue
3
Pages
247–253
Identifiers
PMID: 6223956
Source
Medline
License
Unknown

Abstract

We evaluated if Medroxyprogesterone acetate (MPA) had an immunosuppressive action as progesterone and other steroid hormones. Lymphocyte function was evaluated by the blastogenic response to mitogens and by the E-rosette test. MPA was tested at 7 ng/ml and 100 ng/ml concentrations. Cells were either preincubated for 30 min., 90 min., 180 min. and 12 hr or incubated with MPA for 72 hr, 18 hr and 16 hr. MPA showed a significative inhibitory effect only when used at the concentration of 100 ng/ml.

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