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No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.

Authors
  • Pauli-Magnus, Christiane
  • Feiner, John
  • Brett, Claire
  • Lin, Emil
  • Kroetz, Deanna L
Type
Published Article
Journal
Clinical pharmacology and therapeutics
Publication Date
Nov 01, 2003
Volume
74
Issue
5
Pages
487–498
Identifiers
PMID: 14586389
Source
Medline
License
Unknown

Abstract

There was no association between the MDR1 C3435T variation and plasma levels or central nervous system effects of the P-glycoprotein substrate loperamide in a white study population. The MDR1 haplotype structure was quite variable and supports the use of haplotypes instead of single nucleotide polymorphisms in determining clinical consequences of genetic variation.

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