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Effect of lupeol isolated from Crataeva nurvala Buch.-Ham. stem bark extract against free radical induced nephrotoxicity in rats.

Authors
  • Shirwaikar, Annie
  • Setty, Manjunath
  • Bommu, Praveen
Type
Published Article
Journal
Indian journal of experimental biology
Publication Date
Jul 01, 2004
Volume
42
Issue
7
Pages
686–690
Identifiers
PMID: 15339033
Source
Medline
License
Unknown

Abstract

Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.

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