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The effect of low-intensity pulsed ultrasound on bone-tendon junction healing: Initiating after inflammation stage.

Authors
  • Lu, Hongbin1
  • Liu, Feifei1
  • Chen, Huabin1
  • Chen, Can1
  • Qu, Jin1
  • Xu, Daqi1
  • Zhang, Tao1
  • Zhou, Jingyong1
  • Hu, Jianzhong2
  • 1 Department of Sports Medicine, Research Center of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China. , (China)
  • 2 Department of Spine Surgery, Research Center of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China. [email protected] , (China)
Type
Published Article
Journal
Journal of Orthopaedic Research®
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 01, 2016
Volume
34
Issue
10
Pages
1697–1706
Identifiers
DOI: 10.1002/jor.23180
PMID: 26833973
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The purpose of this study was to explore the effect of low-intensity pulsed ultrasound (LIPUS) treatment initiating after inflammation stage on the process of bone-tendon junction (BTJ) healing in a rabbit model. Thirty-six rabbits undergoing partial patellectomy were randomly divided into two groups: control and LIPUS. The period of initial inflammatory stage is 2 weeks. So LIPUS treatment was initiated at postoperative week 2 and continued until the patella-patellar tendon (PPT) complexes were harvested at postoperative weeks 4, 8, and 16. At each time point, the PPT complexes were harvested for qRT-PCR, histology, radiographs, synchroton radiation micro computed tomography (SR-µCT), and biomechanical testing. The qRT-PCR results showed that LIPUS treatment beginning at postoperative week 2 played an anti-inflammatory role in BTJ healing. Histologically, the LIPUS group showed more advanced remodeling of the lamellar bone and marrow cavity than the control group. The area and length of the new bone in the LIPUS group were significantly greater than the control group at postoperative weeks 8 and 16. SR-µCT demonstrated that new bone formation and remodeling in the LIPUS group were more advanced than the control group. Biomechanical test results demonstrated that the failure load, ultimate strength and energy at failure were significantly higher than those of the control group. In conclusion, LIPUS treatment beginning at postoperative week 2 was able to accelerate bone formation during the bone-tendon junction healing process and significantly improved the healing quality of BTJ injury. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1697-1706, 2016. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

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