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Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic.

Authors
  • She, Chang1
  • Shi, Gao-Long1
  • Xu, Wei1
  • Zhou, Xiao-Zhong1
  • Li, Jian2
  • Tian, Ye3
  • Li, Jian1
  • Li, Wei-Hao4
  • Dong, Qi-Rong5
  • Ren, Pei-Gen6
  • 1 Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, China. , (China)
  • 2 Department of Translational Medicine R&D Center, Shenzhen Institute of Advanced Technology, CAS, Guangdong, Shenzhen, China. , (China)
  • 3 Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soo-chow University, Jiangsu, Suzhou, China. , (China)
  • 4 Department of Radiotherapy and Oncology, The Second Clinical Medical College of Jinan University, Shenzhen, China. , (China)
  • 5 Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, China. [email protected] , (China)
  • 6 Department of Translational Medicine R&D Center, Shenzhen Institute of Advanced Technology, CAS, Guangdong, Shenzhen, China. [email protected] , (China)
Type
Published Article
Journal
Journal of Orthopaedic Research®
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 01, 2016
Volume
34
Issue
10
Pages
1688–1696
Identifiers
DOI: 10.1002/jor.23179
PMID: 26826053
Source
Medline
Keywords
License
Unknown

Abstract

Low-dose irradiation (LDI) exhibits a positive effect on osteoblasts and inhibitory effect of inflammation. Here, we test the hypothesis that LDI can promote osseointegration and inhibit the inflammatory membrane formation in the presence of titanium (Ti) particles. Endotoxin-free titanium particles were injected into rabbit, prior to the insertion of a Ti6-Al-4-V sticks pre-coated with hydroxyapatite. Two days after operation, both distal femurs of the animal were exposed to 0.5 Gy X-ray irradiation. All ani-mals were euthanized 8 weeks after the operation. The PINP concentration was determined at day 0, 2, 4, and 8 weeks after operation. Trabecular morphology around the implants 8 weeks after operation was assessed using micro-CT, then the maximum push out force of simples was assessed using biomechanics test. Five samples in each group were chosen for bone histomorphology study without decalcification 8 weeks after operation. The results confirmed that the LDI can significantly improve ingrowth of bone into the prosthetic interface and stability of the prosthesis when there was no wear particles. Although promotion effects for bone formation induced by LDI can be counteracted by wear particles, LDI can significantly inhibit the interface membrane formation around the implant induced by wear particles. Based on these results, we conclude that LDI may be useful for enhancing the stability of prosthesis when there are no wear particles and for inhibiting the interface membrane formation during the early stage of aseptic loosening in the presence of wear particles. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1688-1696, 2016.

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