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Effect of long-term neuroleptic treatment on prolactin and norepinephrine levels in serum of chronic schizophrenics: relations to psychopathology and extrapyramidal symptoms.

Authors
Type
Published Article
Journal
Neuropsychobiology
Publication Date
Volume
6
Issue
4
Pages
181–189
Identifiers
PMID: 6104798
Source
Medline
License
Unknown

Abstract

The estimation of serum prolactin (Prl) and norepinephrine (NE) in chronic schizophrenics treated with neuroleptics for 5-25 years showed no elevated Prl levels in either men or women (4.9 +/- 4.1 and 13.7 +/- 12.1 ng/ml, respectively). No significant correlation to duration or dosage of neuroleptic treatment, psychopathological syndromes and occurrence of tardive dyskinesia or parkinsonian side effects could be seen. The development of tolerance of the tuberoinfundibular dopamine system is discussed. The NE levels were distinctly elevated in both sexes; in men up to 0.77 +/- 0.4 and in women up to 0.90 +/- 0.48 ng/ml. This elevation is induced rather by neuroleptic treatment than by external factors. A significant relationship between dosage or duration of anticholinergic treatment and the severity of tardive dyskinesia was found in men.

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