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Effect of lofepramine on 5-HT function and sleep.

Authors
  • Herdman, J R
  • Cowen, P J
  • Campling, G M
  • Hockney, R A
  • Laver, D
  • Sharpley, A L
Type
Published Article
Journal
Journal of Affective Disorders
Publisher
Elsevier
Publication Date
Sep 01, 1993
Volume
29
Issue
1
Pages
63–72
Identifiers
PMID: 8254146
Source
Medline
License
Unknown

Abstract

We studied the effect of the tricyclic antidepressant lofepramine (140-210 mg daily for 16 days) on 5-hydroxytryptamine 1A (5-HT1A) receptor sensitivity in healthy volunteers, using a buspirone neuroendocrine challenge paradigm (30 mg orally). We also studied the effect of lofepramine on platelet 5-HT content and sleep architecture. Lofepramine treatment did not alter the hypothermic, endocrine or amnesic effects of buspirone but significantly lowered platelet 5-HT content and decreased rapid eye movement sleep. Our findings suggest that at clinically used doses, lofepramine inhibits the uptake of 5-HT and produces changes in sleep architecture characteristic of tricyclic antidepressants. However, lofepramine does not appear to alter the sensitivity of 5-HT1A receptors.

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