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Effect of local urokinase on arterial occlusion of lower limbs.

Authors
Type
Published Article
Journal
Thrombosis and haemostasis
Publication Date
Volume
45
Issue
3
Pages
230–232
Identifiers
PMID: 7025340
Source
Medline
License
Unknown

Abstract

Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 patients showed that local arterial plasminemia occurred in only 1 patient. Local urokinase does not strongly stimulate "endogenous" thrombolysis and enhances "exogenous" thrombolysis only very inconstantly. A better adaptation of urokinase dosage or the use of an agent with higher affinity for fibrin might improve the efficiency of local thrombolytic therapy.

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