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Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.

Authors
Type
Published Article
Journal
Microvascular research
Publication Date
Volume
57
Issue
3
Pages
357–362
Identifiers
PMID: 10329263
Source
Medline
License
Unknown

Abstract

Recent studies have shown that systemic injection of anti-VEGF antibody into tumor-bearing mice results in decreases in tumor vascular permeability, vessel diameters, and tumor regression. Using a similar animal model, we have applied anti-VEGF antibody directly to the tumor tissue growing in transparent window chambers in SCID mice. Similar to the results obtained with systemic injection, vascular permeability was greatly reduced, but the response was reached at much lower concentrations with local application. Implications of these findings on local control of tumors are discussed.

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