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The effect of Liv-52 on liver ischemia reperfusion damage in rats

Authors
  • Cimen, Orhan1
  • Eken, Hüseyin1
  • Keskin Cimen, Ferda1
  • Cekic, Arif Burak2
  • Kurt, Nezahat1
  • Ozbek Bilgin, Asli1
  • Suleyman, Bahadir1
  • Suleyman, Halis1
  • Mammadov, Renad1
  • Pehlivanoglu, Kamil1
  • Kurnaz, Eray1
  • 1 Erzincan Binali Yildirim University, Erzincan, 24100, Turkey , Erzincan (Turkey)
  • 2 Karadeniz Technical University, Trabzon, 61000, Turkey , Trabzon (Turkey)
Type
Published Article
Journal
BMC Pharmacology and Toxicology
Publisher
Springer Science and Business Media LLC
Publication Date
Jan 03, 2020
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s40360-019-0380-0
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundLiver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats.MethodsAlbino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals.ResultsIncreased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically.ConclusionsLiv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.

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