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Effect of ligustrazine on expression of adherent molecule CD49d and cyclin D2 in hematopoietic cells in acute radiation injured mice.

Authors
  • Dong, L
  • Sun, H
  • Liu, W
  • Tao, D
  • Zhang, Y
  • Xu, H
Type
Published Article
Journal
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao
Publication Date
Jan 01, 1999
Volume
19
Issue
2
Pages
99–101
Identifiers
PMID: 12840848
Source
Medline
License
Unknown

Abstract

After irradiation by 8.0 Gy gamma-ray, each mouse was stomach-fed by 4 mg ligustrazine injection twice a day. On the 7th day after irradiation, CD49d expression in ligustrazine-treated group was significantly higher than that in control group (P < 0.01), and showed no difference from that in normal group (P > 0.05). On the 14th day after irradiation. CD49d expression was increased in control group, but decreased significantly in ligustrazine-treated group (P < 0.01). The expression of Cyclin D2 in spleen mononuclear cells (MNC) in ligustrazine-treated group was significantly higher than that in control group, but the ratio of G0 + G1 phase cells was significantly lower in ligustrazine-treated group (P < 0.01). This finding indicated that ligustrazine could increase the expression of adherent molecule on bone marrow hematopoietic cells and Cyclin D2 in spleen MNC, thereby promoting the growth of hematopoietic cells.

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