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Effect of lamotrigine and environmental enrichment on spatial memory and other behavioral functions in rats.

Authors
  • Nowakowska, Elzbieta
  • Czubak, Anna
  • Kus, Krzysztof
  • Metelska, Jana
  • Burda, Kinga
  • Nowakowska, Anna
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Jan 01, 2010
Volume
60
Issue
6
Pages
307–314
Identifiers
DOI: 10.1055/s-0031-1296292
PMID: 20648919
Source
Medline
License
Unknown

Abstract

Epileptic patients are at risk of experiencing cognitive deficits as a result of pharmacotherapy as well as etiology of epilepsy. Antiepileptic drugs increase inhibitory neurotransmission and reduce the responsiveness of neurons, and thereby may have a negative impact on memory. The enriched environment intensifies exploration of the new area behavior, which may have a positive impact on spatial memory in rats. Depression is among the most common affective disorders in epileptic patients, and using antidepressant drugs together with antiepileptics brings about the risk of interactions and intensifying side effects, The aim of the study was to assess the effects of lamotrigine (CAS 84057-84-1, LTG) (10 mg/kg i.p.), a new anticonvulsant with antidepresssant and neuroprotective properties, for memory and other behavioral functions in rats in standard and enriched environments (EE). LTG improved spatial memory upon repeated administration of the drug both in the rats housed in standard conditions and those housed in EE. Exposure to an enriched environmentsignificantly improved spatial learning. LTG showed antidepressant effect on the forced swimming test both in the rats housed in standard conditions and those housed in EE. In rats housed in EE the antidepressant effect occurred earlier. LTG had a low profile of adverse effects (activity meter, chimney test).

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