Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: Role of lipid accumulation

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Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: Role of lipid accumulation

Authors
  • Patrick Bruneval
  • Jagadeesh Bayry
  • Shivashankar Othy
  • Isabelle Dugail
  • Sebastien Lacroix-Desmazes
  • Srini V. Kaveri
  • Francisco Delers
Type
Published Article
Journal
Journal of Autoimmunity
Publisher
Elsevier
Volume
39
Issue
3
Pages
168–172
Identifiers
DOI: 10.1016/j.jaut.2012.05.013
Source
CdV-UPMC
Keywords
License
Unknown

Abstract

a b s t r a c t Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, poly-specific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasingly used in the therapy of a large number of autoimmune conditions. Despite its successful use in immunopathologies for over two decades, the precise mechanisms underlying the therapeutic benefit have not been fully elucidated. We and others have demonstrated that IVIg inhibits the antigen uptake and presentation by dendritic cells (DC). Here we report that IVIg-mediated inhibition of uptake and processing of antigens is associated with an increased accumulation of lipid as analyzed by flow cytometry and electron microscopy. As accumulation of lipids in DC is known to impart tolerogenic properties, these findings unravel novel link between antibodies and intracellular physiology of innate cells and may further uncover novel immu-noregulatory mechanisms of IVIg in auto-inflammatory diseases.

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