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Effect of iron supplementation on oxidative stress and intestinal inflammation in rats with acute colitis.

Authors
  • Aghdassi, E
  • Carrier, J
  • Cullen, J
  • Tischler, M
  • Allard, J P
Type
Published Article
Journal
Digestive diseases and sciences
Publication Date
May 01, 2001
Volume
46
Issue
5
Pages
1088–1094
Identifiers
PMID: 11341654
Source
Medline
License
Unknown

Abstract

In this study, we investigated the effect of intraperitoneal iron dextran (100 mg/100 g body weight) on oxidative stress and intestinal inflammation in rats with acute colitis induced by 5% dextran sulfate sodium. In both colitis and healthy animals, disease activity index, crypt and inflammatory scores, colon length, plasma and colonic lipid peroxides, and plasma vitamins E, C, and retinol were assessed. The results showed that iron-supplemented groups had moderate iron deposition in the colonic submucosa and lamina propria. In the colitis group supplemented with iron, colon length was significantly shorter; disease activity index, crypt, and inflammatory scores and colonic lipid peroxides were significantly higher; and plasma alpha-tocopherol was significantly lower compared to the colitis group without iron supplementation. There was no intestinal inflammation and no significant increase in colonic lipid peroxides in healthy rats supplemented with iron. In conclusion, iron injection resulted in an increased oxidative stress and intestinal inflammation in rats with colitis but not in healthy rats.

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