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Effect of ionic milieu to the free radicals generated by phenizine methosulphate (PMS).

Authors
Type
Published Article
Journal
Acta physiologica Hungarica
Publication Date
Volume
73
Issue
2-3
Pages
347–349
Identifiers
PMID: 2556890
Source
Medline
License
Unknown

Abstract

The effect of free radicals generated by PMS was studied for membrane damage in the presence of different ions in the erythrocyte model. The degree of membrane damage depended on the quality of ionic composition in the incubation medium. We supposed that the degree of membrane damage depends on the average life and concentration and/or reactivity of the free radicals generated. For control of this supposition free radicals were generated by PMS in the presence of Sodium-di-thionite in isosmotic, waterly systems with different ionic composition. At different time intervals the concentration of free radicals was measured by the ESR method. It seams that concentration of radicals depends on the qualitative composition of ionic milieu. The increase of the average life of free radicals generated by PMS is accompanied by decrease in their reactivity. This is reflected by a moderate membrane damage.

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