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Effect of intravenously administered lipoxygenase metabolites on rat tracheal mucous gel layer thickness.

Authors
Type
Published Article
Journal
International archives of allergy and applied immunology
Publication Date
Volume
90
Issue
3
Pages
307–309
Identifiers
PMID: 2556352
Source
Medline
License
Unknown

Abstract

The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D4 and E4 (LTD4, LTE4) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE greater than 12-HETE greater than or equal to 5-HETE greater than LTD4 greater than or equal to LTE4. Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat.

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