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Effect of intravenous lignocaine infusion on bispectral index during spinal anaesthesia for caesarean section: A prospective randomised double-blind study

  • Khezri, Marzieh Beigom
  • Rajabi, Maryam
  • Yaghoobi, Siamak1
  • Barikani, Ameneh2
  • 1 Department of Anesthesiology, Qazvin University of Medical Sciences, Qazvin, Iran
  • 2 Department of Community and Preventive Medicine, Faculty of Medicine, Qazvin, Iran
Published Article
Indian Journal of Anaesthesia
Wolters Kluwer - Medknow
Publication Date
May 01, 2020
DOI: 10.4103/ija.IJA_424_19
PMID: 32724244
PMCID: PMC7286398
PubMed Central


Background and Aims: Systemic lignocaine has been shown to have sedative effects. We designed this randomised-double-blind, placebo-controlled study to evaluate the effect of intravenous lignocaine on the bispectral index (BIS) during caesarean section under spinal anaesthesia. Methods: 80 patients scheduled for elective caesarean section under spinal anaesthesia were randomly allocated to 2 study groups. Group L received intravenous 1.5 mg/kg of lignocaine bolus, 15 minutes before spinal anaesthesia followed by an intravenous infusion 1.5 mg/kg/h for 60 minutes intravenously. The patients in the control group (C group) were given 0.9% sodium chloride in a double-blind fashion. Spinal anaesthesia was performed with 10 mg of 0.5% bupivacaine. The changes of Sao2, BIS and hemodynamic variables during caesarean section, Apgar score of neonate and the incidence of adverse effects were recorded. Results: BIS values were lower in the L group compared to C group ( P ≤ 0.001). Comparison of mean arterial pressure (MAP) changes during spinal anaesthesia and surgery reveal statistically significant difference between two groups through repeated measure analysis ( P ≤ 0.001), but comparision of heart rate (HR) changes during spinal anaesthesia and surgery failed to reveal any statistically significant difference between two groups. ( P = 0.261). The Apgar scores did not reveal a significant difference between the two groups at first and five minutes after delivery ( P = 0.99). Conclusion: Intravenous lignocaine infusion given with spinal anaesthesia in women undergoing elective caesarean delivery providing lower BIS values without respiratory depression, in the absence of foetal compromise.

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