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Effect of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas.

Authors
Type
Published Article
Journal
The Journal of pathology
Publication Date
Volume
183
Issue
4
Pages
460–468
Identifiers
PMID: 9496264
Source
Medline
License
Unknown

Abstract

Interleukin-6 (IL-6) has been shown to be released by cultured human meningioma cells and may be a positive or negative regulator of tumour growth. IL-6 protein and mRNA levels have been examined in a series of meningiomas. In 14 cases, the results are compared with the effects of IL-6 and dexamethasone on growth and IL-6 secretion in vitro. Tumours with the highest in vivo IL-6 mRNA expression also showed maximum induction of IL-6 and increased cellular proliferation on IL-1 stimulation in vitro. Dexamethasone decreased the IL-1-stimulated IL-6 release in all cases. Meningiomas which had little or no IL-6 message were refractory to IL-1 control of IL-6. Remarkably, these formed the group of meningiomas that increased their growth rate in response to dexamethasone.

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