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The effect of insomnia on development of Alzheimer’s disease

Authors
  • Sadeghmousavi, Shaghayegh1, 2
  • Eskian, Mahsa1, 3, 4
  • Rahmani, Farzaneh1, 3, 5
  • Rezaei, Nima1, 3, 4, 3
  • 1 Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran , Tehran (Iran)
  • 2 Shahid Beheshti University of Medical Sciences, Tehran, Iran , Tehran (Iran)
  • 3 Tehran University of Medical Sciences, Tehran, Iran , Tehran (Iran)
  • 4 Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran , Tehran (Iran)
  • 5 Washington University in St. Louis, St. Louis, MO, USA , St. Louis (United States)
Type
Published Article
Journal
Journal of Neuroinflammation
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 06, 2020
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s12974-020-01960-9
Source
Springer Nature
Keywords
License
Green

Abstract

Alzheimer’s disease (AD) is the most common type of dementia and a neurodegenerative disorder characterized by memory deficits especially forgetting recent information, recall ability impairment, and loss of time tracking, problem-solving, language, and recognition difficulties. AD is also a globally important health issue but despite all scientific efforts, the treatment of AD is still a challenge. Sleep has important roles in learning and memory consolidation. Studies have shown that sleep deprivation (SD) and insomnia are associated with the pathogenesis of Alzheimer’s disease and may have an impact on the symptoms and development. Thus, sleep disorders have decisive effects on AD; this association deserves more attention in research, diagnostics, and treatment, and knowing this relation also can help to prevent AD through screening and proper management of sleep disorders. This study aimed to show the potential role of SD and insomnia in the pathogenesis and progression of AD.

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