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The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study

Authors
  • Lorenzo, Isabel Salas
  • Tonato, Aida M. Chisaguano
  • Puentes, Andrea de la Garza
  • Nieto, Ana
  • Herrmann, Florian
  • Dieguez, Estefanía
  • Castellote, Ana I.
  • López-Sabater, Carmen
  • Rodríguez-Palmero, Maria
  • Campoy, Cristina
Publication Date
Mar 12, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age. FADS minor allele carriership in formula fed infants, especially those supplemented, was associated with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected, possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.

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