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[Effect of indomethacin on bronchial reactivity to supernatant of mononuclear cell cultures from patients with bronchial asthma].

Authors
  • Krasnowska, M
  • Małolepszy, J
Type
Published Article
Journal
Pneumonologia polska
Publication Date
Jan 01, 1990
Volume
58
Issue
11-12
Pages
604–609
Identifiers
PMID: 8614650
Source
Medline
License
Unknown

Abstract

In 27 asthmatic patients a cell culture was made from mononuclear cell stimulated by PHA. Indomethacin was added to part of the cultures. After 2 days the culture was terminated and the supernatant was prepared for bronchoprovocation studies. Patients underwent baseline respiratory function studies, after which bronchial provocation was carried out with different concentrations of the supernatant. Bronchial provocation using supernatant from cells cultured with indomethacin produced significant respiratory function alterations in comparison with tests carried out with supernatant from cells stimulated with PHA.

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