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Effect of increasing the dose and duration of sertraline trial in the treatment of depressed nursing home residents.

Authors
  • Weintraub, Daniel
  • Streim, Joel E
  • Datto, Catherine J
  • Katz, Ira R
  • DiFilippo, Suzanne D
  • Oslin, David W
Type
Published Article
Journal
Journal of geriatric psychiatry and neurology
Publication Date
Jun 01, 2003
Volume
16
Issue
2
Pages
109–111
Identifiers
PMID: 12801161
Source
Medline
License
Unknown

Abstract

There has been limited research into defining what constitutes an adequate first-line antidepressant trial in elderly patients. The authors report the outcome of extended, high-dosage sertraline treatment in a sample of nursing home residents experiencing residual significant depressive symptoms after 10 weeks of treatment with sertraline at a final dosage of 100 mg/day. Subjects who had a Hamilton Depression Rating Scale score > or = 12 after 10 weeks of treatment with sertraline were eligible for the 8-week open-label extension phase, which involved titrating the sertraline dosage to 200 mg/day. The cumulative response rate was 52% for the extension phase, compared with 37% for the acute phase. Examining acute phase nonresponders, 39% responded during the extension phase. Rates of discontinuation due to adverse events were comparable in the 2 phases. Our findings suggest that an extended trial or high dosages of sertraline may benefit some depressed elderly patients with persistent depression after acute treatment.

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