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Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes

Authors
  • Xia, Shengli1
  • Duan, Kai2
  • Zhang, Yuntao3
  • Zhao, Dongyang1
  • Zhang, Huajun4
  • Xie, Zhiqiang1
  • Li, Xinguo2
  • Peng, Cheng4
  • Zhang, Yanbo5
  • Zhang, Wei1
  • Yang, Yunkai3
  • Chen, Wei2
  • Gao, Xiaoxiao4
  • You, Wangyang1
  • Wang, Xuewei3
  • Wang, Zejun2
  • Shi, Zhengli4
  • Wang, Yanxia1
  • Yang, Xuqin3
  • Zhang, Lianghao2
  • And 17 more
  • 1 Henan Center for Disease Control and Prevention, Zhengzhou, Henan, China
  • 2 National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co Ltd, Wuhan, Hubei, China
  • 3 China National Biotec Group Company Limited, Beijing, China
  • 4 Chinese Academy of Sciences Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China
  • 5 Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • 6 Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China
  • 7 National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, Hubei, China
Type
Published Article
Journal
JAMA
Publisher
American Medical Association
Publication Date
Aug 13, 2020
Volume
324
Issue
10
Pages
1–10
Identifiers
DOI: 10.1001/jama.2020.15543
PMID: 32789505
PMCID: PMC7426884
Source
PubMed Central
Disciplines
  • Online First
License
Unknown
External links

Abstract

This interim analysis of 2 randomized trials compares adverse reactions and neutralizing antibody responses to inactivated coronavirus disease 2019 (COVID-19) vs adjuvant-only control vaccination, and compares the outcomes at varying vaccine doses among healthy adults in China.

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