Administration of immosimase, a proteolytic enzyme complex developed in Russia, provoked active Tb discharge when the latter is occult in cases of destructive tuberculosis. Inhalation of the preparation enriches the patients' sputum with the bacilla. This permitted active tuberculosis diagnosis in additional 28% of the examinees.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/8127839