Affordable Access

Effect of immobilization stress on pipecolic acid transport in mouse brain areas and peripheral tissues.

Authors
  • Nishio, H
  • Sogabe, H
  • Segawa, T
Type
Published Article
Journal
Neurochemistry International
Publisher
Elsevier
Publication Date
Jan 01, 1988
Volume
13
Issue
2
Pages
217–221
Identifiers
PMID: 20501290
Source
Medline
License
Unknown

Abstract

Transport activity of d-pipecolic acid and of l-pipecolic acid in mouse brain and peripheral tissues were tested, and the effect of immobilization stress was described, along with the method for preparative, enantiomeric resolution and purification of d,l-pipecolic acid using high performance liquid chromatography equipped with a chiral column. It was found that l-isomer, an endogenous substance, was more rapidly transported to brain and liver than the d-isomer, non-endogenous one, which was more rapidly eliminated into the kidney. Immobilization stress caused acceleration of transport of l-pipecolic acid into the brain region, liver and heart, but not that of d-pipecolic acid. From these results it was suggested that the elevation of pipecolic acid concentration caused by stress might be exerted through its stimulatory effect on the transport of l-pipecolic acid into the tissues.

Report this publication

Statistics

Seen <100 times