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[Effect of hypoosmotic stimulation of the gastrointestinal mucosa on the activity of NA+, K+-atpase of epithelial cells in the small intestine and kidney in rats].

Authors
  • Iaremenko, M S
  • Prokopenko, O M
  • Vavilova, G L
  • Kharlamova, O M
Type
Published Article
Journal
Fiziologicheskiĭ zhurnal
Publication Date
Jan 01, 1992
Volume
38
Issue
6
Pages
93–97
Identifiers
PMID: 1340459
Source
Medline
License
Unknown

Abstract

The experiments on Wistar rats have shown that intragestral injection with mannitol hypotonic solution (20 mmol/l) causes the significant activation of Na+, K(+)-ATPase of duodenum and distal intestine epithelial cells, kidney cortex cells, but does not affect the brain cortex of Na+, K(+)-ATPase activity. Simultaneously the activator of enzyme (AE) enters blood serum of rats, its activity is revealed by blood serum addition to homogenates of tissues of control rats. It is assumed that AE is produced in duodenal and intestinal mucosa released to blood after stimulation of mucosal surface by hypotonic solutions and included into the osmoregulation processes on the Na+, K(+)-ATPase level.

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