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Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs.

Authors
  • Sánchez de León, R
  • Brajkovich, I
  • Zabner, J
  • Martinez-Ruiz, R
  • Angeli, S
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Apr 01, 1986
Volume
14
Issue
4
Pages
285–287
Identifiers
PMID: 3082594
Source
Medline
License
Unknown

Abstract

Fluid filtration rate (FFR) was measured under predominantly zone-three conditions in isolated rabbit lung perfused at constant flow. During forward and reverse perfusion, alveolar hypercapnia significantly increased mean pulmonary artery pressure but did not change FFR. We conclude that the pulmonary vasoconstriction induced by alveolar hypercapnia occurs on both arterial and venular sides of the pulmonary circulation.

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