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Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly( N -isopropylacrylamide-co-dopamine Methacrylamide) Copolymers

Authors
  • García-Peñas, Alberto1, 2
  • Biswas, Chandra Sekhar1
  • Liang, Weijun1
  • Wang, Yu1
  • Yang, Pianpian3
  • Stadler, Florian J.1
  • 1 (Y.W.)
  • 2 Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
  • 3 Department of Management, Shenzhen University, Shenzhen 518060, China
Type
Published Article
Journal
Polymers
Publisher
MDPI AG
Publication Date
Jun 04, 2019
Volume
11
Issue
6
Identifiers
DOI: 10.3390/polym11060991
PMID: 31167423
PMCID: PMC6630648
Source
PubMed Central
Keywords
License
Green

Abstract

For the preparation of thermoresponsive copolymers, for e.g., tissue engineering scaffolds or drug carriers, a precise control of the synthesis parameters to set the lower critical solution temperature (LCST) is required. However, the correlations between molecular parameters and LCST are partially unknown and, furthermore, LCST is defined as an exact temperature, which oversimplifies the real situation. Here, random N-isopropylacrylamide (NIPAM)/dopamine methacrylamide (DMA) copolymers were prepared under a systematical variation of molecular weight and comonomer amount and their LCST in water studied by calorimetry, turbidimetry, and rheology. Structural information was deduced from observed transitions clarifying the contributions of molecular weight, comonomer content, end-group effect or polymerization degree on LCST, which were then statistically modeled. This proved that the LCST can be predicted through molecular structure and conditions of the solutions. While the hydrophobic DMA lowers the LCST especially the onset, polymerization degree has an important but smaller influence over all the whole LCST range.

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