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[Effect of HLA- genotype on bacterial colonization and antigenemia in patients with infiltrative pulmonary tuberculosis].

Authors
Type
Published Article
Journal
Problemy tuberkuleza
Publication Date
Issue
5
Pages
35–37
Identifiers
PMID: 8295884
Source
Medline
License
Unknown

Abstract

150 patients with infiltrative tuberculosis (IT) and 135 healthy subjects were subjected to HLA-typing. Clinico-immunogenetic correlations provided evidence for significantly higher incidence of antigens A11, B12, Cw2, DR2, DR5 in IT patients versus healthy subjects. Antigens Cw3 and DR2 occur more frequently in progressive disease. IT patients disseminating M. tuberculosis carry more frequently antigens HLA-DR2, those with L-forms DR5, with antigenemia antigens HLA-DR2 and DR4.

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