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Effect of high- versus intermediate-purity blood coagulation factor concentrates on HIV-1 replication.

Authors
  • Schögl, D
  • Zimmermann, K
  • Turecek, P L
  • Schwarz, H P
  • Eibl, M M
  • Mannhalter, J W
Type
Published Article
Journal
Vox sanguinis
Publication Date
Jan 01, 1996
Volume
70
Issue
4
Pages
195–197
Identifiers
PMID: 9123922
Source
Medline
License
Unknown

Abstract

Controversy exists as to whether treatment of HIV-1-seropositive hemophiliacs with blood coagulation products of high purity might help prevent the decline of CD4-positive lymphocytes and thus delay progression toward AIDS. As viral load has recently been shown to be associated with disease progression in HIV-1 infection, we tested for a possible direct interference of high- or intermediate-purity blood coagulation products with replication of HIV-1. The data obtained revealed comparable replication of HIV-1 in the presence and absence of all blood coagulation products tested (assessed by PCR-based quantitation of proviral HIV-1 DNA in infected cells after a 10-day incubation period). These data suggest that coagulation factor concentrates per se will also have no direct effect on HIV-1 replication in vivo.

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