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Effect of heparan sulphate on kidney tissue expression of TGF-beta, rhoA, laminin and fibronectin in subtotally nephrectomized rats.

Authors
  • Bernardini, Nunzia
  • Cupisti, Adamasco
  • Mattii, Letizia
  • Segnani, Cristina
  • Dolf, Amelio
  • Barsotti, Massimiliano
  • Barsotti, Giuliano
Type
Published Article
Journal
Journal of nephrology
Publication Date
Jan 01, 2002
Volume
15
Issue
5
Pages
530–538
Identifiers
PMID: 12455720
Source
Medline
License
Unknown

Abstract

HS treatment is associated with significantly lower renal expression of TGF-beta, laminin and fibronectin, but not of RhoA. This suggests that the renal-protective effect of HS may be obtained by modulating the TGF-beta pathway, independently of RhoA-mediated transduction.

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