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Effect of Hallucinogens on Unconditioned Behavior.

Authors
  • Halberstadt, Adam L1, 2
  • Geyer, Mark A3, 4
  • 1 Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093-0804, USA. [email protected]
  • 2 Research Service, VA San Diego Healthcare System, San Diego, CA, USA. [email protected]
  • 3 Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093-0804, USA.
  • 4 Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
Type
Published Article
Journal
Current topics in behavioral neurosciences
Publication Date
Jan 01, 2018
Volume
36
Pages
159–199
Identifiers
DOI: 10.1007/7854_2016_466
PMID: 28224459
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Because of the ethical and regulatory hurdles associated with human studies, much of what is known about the psychopharmacology of hallucinogens has been derived from animal models. However, developing reliable animal models has proven to be a challenging task due to the complexity and variability of hallucinogen effects in humans. This chapter focuses on three animal models that are frequently used to test the effects of hallucinogens on unconditioned behavior: head twitch response (HTR), prepulse inhibition of startle (PPI), and exploratory behavior. The HTR has demonstrated considerable utility in the neurochemical actions of hallucinogens. However, the latter two models have clearer conceptual bridges to human phenomenology. Consistent with the known mechanism of action of hallucinogens in humans, the behavioral effects of hallucinogens in rodents are mediated primarily by activation of 5-HT2A receptors. There is evidence, however, that other receptors may play secondary roles. The structure-activity relationships (SAR) of hallucinogens are reviewed in relation to each model, with a focus on the HTR in rats and mice.

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