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Effect of haemolysis on reticuloendothelial system (RES) phagocytic activity in rats.

Authors
  • Trop, M
  • Schiffrin, E R
  • Carter, E A
Type
Published Article
Journal
Burns
Publisher
Elsevier
Publication Date
Aug 01, 1991
Volume
17
Issue
4
Pages
288–289
Identifiers
PMID: 1930661
Source
Medline
License
Unknown

Abstract

The role of haemolysis of blood in the alterations in the uptake of [99mTc]SC ([99mTc]-sulphur colloid) in vivo in the rat has been examined. When the haemolysed blood (produced by first freezing the blood in liquid nitrogen) was infused into synergenic Lewis rats via the tail vein, there was a significant reduction in the uptake of the [99mTc]SC by the spleen, but lung, liver and kidney uptake remained constant. These results suggest that haemolysis of the blood may play a role in the alterations in RES phagocytic activity observed in the spleen following thermal injury.

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