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[Effect of glucocorticoid on CD4 T-lymphocyte and eosinophil activation in asthmatics].

Authors
Type
Published Article
Journal
Zhonghua nei ke za zhi
Publication Date
Volume
36
Issue
1
Pages
7–10
Identifiers
PMID: 9812552
Source
Medline
License
Unknown

Abstract

To study the influence of oral glucocorticoid on CD4 T-lymphocyte and eosinophil activation in the asthmatics, we collected the serum samples from 14 patients who required oarl glucocorticoid therapy for moderate to severe disease exacerbations and measured the serum interleukin (IL)-5, eosinophil cationic protein (ECP) levels before and after one week with prednisone (20 mg/d) by enzyme-linked immunosorbent assay. The results revealed that after oral prednisone therapy, the serum IL-5, ECP levels and the numbers of peripheral blood eosinophils decreased, whereas the lung function significantly improved. It is suggested that glucocorticoids might exert antiasthma effect of by inhibiting CD4 T-lymphocyte activation and cytokine (e.g., IL-5) secretion.

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