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Effect of freeze-thawing on lipid bilayer-protected gold nanoparticles.

Authors
  • Zhang, Lixue
  • Li, Peicai
  • Li, Dan
  • Guo, Shaojun
  • Wang, Erkang
Type
Published Article
Journal
Langmuir : the ACS journal of surfaces and colloids
Publication Date
Apr 01, 2008
Volume
24
Issue
7
Pages
3407–3411
Identifiers
DOI: 10.1021/la703737q
PMID: 18278967
Source
Medline
License
Unknown

Abstract

In this study, varieties of lipid bilayer-protected gold nanoparticles (AuNPs) were synthesized through a simple wet chemical method, and then the effect of freeze-thawing on the as-prepared AuNPs was investigated. The freeze-thawing process induced fusion or fission of lipid bilayers tethered on the AuNPs. The UV-vis spectra and transmission electron microscopy experiments revealed that the disruption of lipid bilayer structures on the nanoparticles led to the fusion or aggregation of AuNPs. The role of freeze-thawing in the evolution of lipid bilayer-protected AuNPs was studied. The addition of adequate sucrose, a well-known cryoprotectant, effectively prevented the fusion or aggregation of lipid bilayer-protected AuNPs undergoing the freeze-thawing process. The possible mechanism of sucrose preserving the integrity of the lipid bilayer-protected AuNPs was also discussed.

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