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Effect of FR167653 on Small Bowel Ischemia-Reperfusion Injury in Dogs

Authors
  • Takeyoshi, Izumi
  • Iwanami, Kotaro
  • Ohwada, Susumu
  • Kawashima, Yoshiyuki
  • Kawata, Kiyoshi
  • Aiba, Masaaki
  • Kobayashi, Junya
  • Koyama, Toru
  • Matsumoto, Koshi
  • Satoh, Susumu
  • Morishita, Yasuo
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Nov 01, 1999
Volume
44
Issue
11
Pages
2334–2343
Identifiers
DOI: 10.1023/A:1026633510390
Source
Springer Nature
Keywords
License
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Abstract

IL-1 and TNF-α are known to be pleiotropiccytokines associated with various inflammatoryconditions such as small intestinal injury afterischemia-reperfusion. FR167653 has been characterized asa potent suppressant of IL-1 and TNF-αproduction. The effect of FR167653 on intestinalreperfusion injury was investigated in a warm ischemiamodel of the canine gut. Sixteen mongrel dogs weredivided into two groups: a control group and a FR groupto which FR167653 was administered. Both the superiormesenteric artery and vein were clamped for 2 hr.Arterial pH, hepatic venous hemoglobin oxygensaturation, intramucosal pH, and the survival rate werewell maintained in the FR group in comparison with thecontrol group after reperfusion. FR167653 inhibited theexpression of IL-1β mRNA. Histologically,ischemia-reperfusion injury was more severe in the control groupthan the FR group. This study suggests that FR167653inhibits proinflammatory cytokines and amelioratesischemia-reperfusion injury of the smallintestine.

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