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The effect of fornix deep brain stimulation in brain diseases

Authors
  • Liu, Huajie1, 2
  • Temel, Yasin1, 2
  • Boonstra, Jackson1, 2
  • Hescham, Sarah1, 2
  • 1 Maastricht University Medical Center, Maastricht, 6202 AZ, The Netherlands , Maastricht (Netherlands)
  • 2 Maastricht University, Maastricht, The Netherlands , Maastricht (Netherlands)
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Jan 23, 2020
Volume
77
Issue
17
Pages
3279–3291
Identifiers
DOI: 10.1007/s00018-020-03456-4
Source
Springer Nature
Keywords
License
Green

Abstract

Deep brain stimulation is used to alleviate symptoms of neurological and psychiatric disorders including Parkinson’s disease, epilepsy, and obsessive–compulsive-disorder. Electrically stimulating limbic structures has been of great interest, and in particular, the region of the fornix. We conducted a systematic search for studies that reported clinical and preclinical outcomes of deep brain stimulation within the fornix up to July 2019. We identified 13 studies (7 clinical, 6 preclinical) that examined the effects of fornix stimulation in Alzheimer’s disease (n = 9), traumatic brain injury (n = 2), Rett syndrome (n = 1), and temporal lobe epilepsy (n = 1). Overall, fornix stimulation can lead to decreased rates of cognitive decline (in humans), enhanced memory (in humans and animals), visuo-spatial memorization (in humans and animals), and improving verbal recollection (in humans). While the exact mechanisms of action are not completely understood, studies suggest fornix DBS to be involved with increased functional connectivity and neurotransmitter levels, as well as enhanced neuroplasticity.

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