Spike activity of neurons (areas 3, 4) was studied in cats during conditioned placing reaction before and after food satiation. After feeding the background activity increased in 2/3 of recorded neurons, tonic component of neuronal reaction decreased considerably and repeated contraction of m. biceps disappeared. Difference in the latencies of spike reactions in the same neuron to conditioned stimulation in the hungry and satisfied state of the animal during experiment was 50-300 ms. The latencies of conditioned placing reaction did not change. It was suggested that fluctuations of the food motivation level of animals lead to changes in the cortico-subcortical interrelations responsible for control of the start and realization of conditioned movements.