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Effect of fish oil treatment on gentamicin nephrotoxicity in rats.

Authors
  • Ali, B H
  • Bashir, A A
Type
Published Article
Journal
Annals of nutrition & metabolism
Publication Date
Jan 01, 1994
Volume
38
Issue
6
Pages
336–339
Identifiers
PMID: 7702362
Source
Medline
License
Unknown

Abstract

The effect of fish oil on gentamicin-induced nephrotoxicity was investigated in rats. Gentamicin (80 mg/kg/day intramuscularly for 6 days) produced the typical pattern of nephrotoxicity as shown by increases in serum creatinine and urea concentrations, and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity and proximal renal tubular necrosis. Fish oil (5.0 ml/kg/kday per os for 10 days) partially protected against the nephrotoxicity induced by gentamicin administered during the last 6 days of treatment with fish oil by returning the creatinine and urea concentrations and NAG activity to normal and by ameliorating the histopathological damage. Olive oil (5 mg/kg/day per os for 10 days) was ineffective in protecting rats against gentamicin nephrotoxicity.

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